Neuroplasticity Changes of Rat Brain by Musical Stimuli during Fetal Period
نویسندگان
چکیده
OBJECTIVE Fetal development of the central nervous system is an important and sensitive stage which is affected by many external and internal stimuli. This study aimed to investigate effect of musical stimuli on fetal rat brain. MATERIALS AND METHODS In this experimental study, twelve female Wistar rats were selected and evenly assigned to control and musical groups. The females were mated with a male rat of the same genotype. Musical group was exposed to classic music with 60 dB power for 90 minutes twice per day from 2(nd) to 20(th) day of gestation. The control rats were handled similar to the musical group, but were not exposed to music. Before parturition, all the dams were anesthetized, and their blood samples were obtained and used for corticosterone (COS) measurement. They were transcardially perfused by electron microscope (EM) fixative agent. The fetal brains were extracted intact and used for slice preparation. Horizontal slices were made for electron microscope preparation, and images were taken and analyzed in terms of cell density and morphological changes. RESULTS EM observation indicated significant morphological difference in cellular and intercellular spaces between the two groups. Music-treated fetuses had significantly higher cell density in parietal cortex and music-treated dams had lower COS level. CONCLUSION It was concluded that prenatal music would have a great impact on neuroplasticity of fetal rat brain, at least indirectly. Although the rat fetuses cannot hear until birth, music-induced reduction in COS blood level of dams might be the reason for neuroplasticity of fetal brain.
منابع مشابه
Stress and Perception of Emotional Stimuli: Long-term Stress Rewiring the Brain
Introduction: Long-term stressful situations can drastically influence one’s mental life. However, the effect of mental stress on recognition of emotional stimuli needs to be explored. In this study, recognition of emotional stimuli in a stressful situation was investigated. Four emotional conditions, including positive and negative states in both low and high levels of arousal were analy...
متن کاملP33: Effect of Mother\'s Anxiety on Fetus
The prenatal period is a critical time for neurodevelopment and is thus a period of vulnerability during which a range of exposures have been found to exert long-term changes on brain development and behavior with implications for physical and psychiatric health. During fetal life, neurons proliferate, migrate and form connections, providing the structure of the developing brain. Neurons reach ...
متن کاملThe Effect of Neuroplasticity of the Brain on the Incidence of Anterior Cruciate Ligament Injury and the Effect of Injury this Ligament on Brain Function And Structure (Systematic Review)
Objective: The present study aimed to investigate neuroplasticity of the brain on the incidence of anterior cruciate ligament injury and the effect of injury this ligament on brain function and structure before ligament reconstruction, after ligament reconstruction, and after a period of rehabilitation exercises. Materials & Methods: Previous studies were conducted from PubMed, Scopus, Web of ...
متن کاملThe impact of COVID-19 during pregnancy on fetal brain development
The development of the brain as the most complex structure of the human body is a long process that begins in the third week of pregnancy and continues until adulthood and even until the end of life (1). Human brain myelination begins one to two months before birth in the visual system and eventually lasts until the age of two in other sensory systems and then the motor systems (4). Processes a...
متن کاملThe Effects of Local Fetal Brain Extract Administration on the Electromyogram of Crushed Sciatic Nerve in Rat
To evaluate the effects of local administration of the fetal brain extract (FBE) on the crushed peripheral nerve, 15 male Wistar rats were used. The right sciatic nerve of 10 rats was locally underwent the tense compression for 30 seconds and then randomly divided into experimental and control (sham) groups. The remained rats were considered as intact animals. Treatment was commenced weekly, by...
متن کامل